Membranal tyrosine protein kinase activity (but not cAMP-dependent protein kinase activity) is associated with growth of rat mammary tumors

Yoav Sharoni, Sara Radian, Joseph Levy

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

DMBA induced rat mammary tumors were used to study the association of tyrosine protein kinase activity with tumor growth. Pharmacological manipulations of blood prolactin level, by perphenazine and bromocriptine, were used to stimulate or arrest tumor growth, respectively. During perphenazine treatment, a 2-3-fold increase in membranal tyrosine protein kinase activity, measured with angiotensin II as substrate, preceded the 3-4-fold increase in tumor area. At the same time the cAMP-dependent protein kinase activity, measured with kemptide as substrate, did not change. Tyrosine protein kinase Mammary tumor DMBA Tumor growth.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalFEBS Letters
Volume189
Issue number1
DOIs
StatePublished - 9 Sep 1985

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