TY - JOUR
T1 - Membranal tyrosine protein kinase activity (but not cAMP-dependent protein kinase activity) is associated with growth of rat mammary tumors
AU - Sharoni, Yoav
AU - Radian, Sara
AU - Levy, Joseph
N1 - Funding Information:
This work was supportedi n part by the Beatty Malkin Grant for cancerr esearcha nd grantsf rom the Chief Scientist Office, Israeli Ministry of Health and the Israel Cancer Association. The authorsw ish to thank Mrs M. Duman for her ex-cellente ditorial assistance.
PY - 1985/9/9
Y1 - 1985/9/9
N2 - DMBA induced rat mammary tumors were used to study the association of tyrosine protein kinase activity with tumor growth. Pharmacological manipulations of blood prolactin level, by perphenazine and bromocriptine, were used to stimulate or arrest tumor growth, respectively. During perphenazine treatment, a 2-3-fold increase in membranal tyrosine protein kinase activity, measured with angiotensin II as substrate, preceded the 3-4-fold increase in tumor area. At the same time the cAMP-dependent protein kinase activity, measured with kemptide as substrate, did not change. Tyrosine protein kinase Mammary tumor DMBA Tumor growth.
AB - DMBA induced rat mammary tumors were used to study the association of tyrosine protein kinase activity with tumor growth. Pharmacological manipulations of blood prolactin level, by perphenazine and bromocriptine, were used to stimulate or arrest tumor growth, respectively. During perphenazine treatment, a 2-3-fold increase in membranal tyrosine protein kinase activity, measured with angiotensin II as substrate, preceded the 3-4-fold increase in tumor area. At the same time the cAMP-dependent protein kinase activity, measured with kemptide as substrate, did not change. Tyrosine protein kinase Mammary tumor DMBA Tumor growth.
UR - http://www.scopus.com/inward/record.url?scp=0021929860&partnerID=8YFLogxK
U2 - 10.1016/0014-5793(85)80857-7
DO - 10.1016/0014-5793(85)80857-7
M3 - Article
AN - SCOPUS:0021929860
SN - 0014-5793
VL - 189
SP - 133
EP - 136
JO - FEBS Letters
JF - FEBS Letters
IS - 1
ER -
