Membrane fluctuations around inclusions

Christian D. Santangelo, Oded Farago

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


The free energy of inserting a protein into a membrane is determined by considering the variation in the spectrum of thermal fluctuations in response to the presence of a rigid inclusion. Both numerically and through a simple analytical approximation, we find that the primary effect of fluctuations is to reduce the effective surface tension, hampering the insertion at low surface tension. Our results, which should also be relevant for membrane pores, suggest (in contrast to classical nucleation theory) that a finite surface tension is necessary to facilitate the opening of a pore.

Original languageEnglish
Pages (from-to)103-109
Number of pages7
JournalJournal of Computer-Aided Materials Design
Issue numberSUPPL. 1
StatePublished - 1 Dec 2007


  • Membranes
  • Proteins
  • Surface tension
  • Thermal fluctuations

ASJC Scopus subject areas

  • General Materials Science
  • Computer Science Applications
  • Computational Theory and Mathematics


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