Membrane interactions of ionic liquids: Possible determinants for biological activity and toxicity

Noga Gal, Danilo Malferarri, Sofiya Kolusheva, Paola Galletti, Emilio Tagliavini, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Ionic liquids (ILs) are a class of diverse organic salts with relatively low melting points (below 100 °C) which have attracted considerable interest as a promising green substitute for organic solvents. The broad solvation properties of ILs and their high solubility in water, however, present health risks, in particular since it was shown that many ILs exhibit cytotoxic properties. In this context, interactions of ILs with the cellular membrane are believed to constitute a primary culprit for toxicity. We present a comprehensive biophysical and microscopy study of membrane interactions of a series of ILs having different side-chain compositions and lengths, and cationic head-group structures and orientations. The experimental data reveal that the ILs studied exhibit distinct mechanisms of membrane binding, insertion, and disruption which could be correlated with their biological activities. The results indicate, in particular, that both the side chain composition and particularly the head-groups of ILs constitute determinants for membrane activity and consequent cell toxicity. This work suggests that tuning membrane interactions of ILs should be an important factor for designing future compounds with benign environmental impact.

Original languageEnglish
Pages (from-to)2967-2974
Number of pages8
JournalBiochimica et Biophysica Acta - Biomembranes
Issue number12
StatePublished - 1 Jan 2012


  • FRET
  • Giant vesicle
  • Ionic liquid
  • Membrane
  • Membranes permeation
  • Polydiacetylene

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology


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