TY - JOUR
T1 - Meningeal lymphoid structures are activated under acute and chronic spinal cord pathologies
AU - Cohen, Merav
AU - Giladi, Amir
AU - Raposo, Catarina
AU - Zada, Mor
AU - Li, Baoguo
AU - Ruckh, Julia
AU - Deczkowska, Aleksandra
AU - Mohar, Boaz
AU - Shechter, Ravid
AU - Lichtenstein, Rachel G.
AU - Amit, Ido
AU - Schwartz, Michal
N1 - Publisher Copyright:
© 2020 Cohen et al.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Tertiary lymphoid structures (TLS) are organized aggregates of B and T cells formed ectopically during different stages of life in response to inflammation, infection, or cancer. Here, we describe formation of structures reminiscent of TLS in the spinal cord meninges under several central nervous system (CNS) pathologies. After acute spinal cord injury, B and T lymphocytes locally aggregate within the meninges to form TLS-like structures, and continue to accumulate during the late phase of the response to the injury, with a negative impact on subsequent pathological conditions, such as experimental autoimmune encephalomyelitis. Using a chronic model of spinal cord pathology, the mSOD1 mouse model of amyotrophic lateral sclerosis, we further showed by single-cell RNA-sequencing that a meningeal lymphocyte niche forms, with a unique organization and activation state, including accumulation of pre-B cells in the spinal cord meninges. Such a response was not found in the CNS-draining cervical lymph nodes. The present findings suggest that a special immune response develops in the meninges during various neurological pathologies in the CNS, a possible reflection of its immune privileged nature.
AB - Tertiary lymphoid structures (TLS) are organized aggregates of B and T cells formed ectopically during different stages of life in response to inflammation, infection, or cancer. Here, we describe formation of structures reminiscent of TLS in the spinal cord meninges under several central nervous system (CNS) pathologies. After acute spinal cord injury, B and T lymphocytes locally aggregate within the meninges to form TLS-like structures, and continue to accumulate during the late phase of the response to the injury, with a negative impact on subsequent pathological conditions, such as experimental autoimmune encephalomyelitis. Using a chronic model of spinal cord pathology, the mSOD1 mouse model of amyotrophic lateral sclerosis, we further showed by single-cell RNA-sequencing that a meningeal lymphocyte niche forms, with a unique organization and activation state, including accumulation of pre-B cells in the spinal cord meninges. Such a response was not found in the CNS-draining cervical lymph nodes. The present findings suggest that a special immune response develops in the meninges during various neurological pathologies in the CNS, a possible reflection of its immune privileged nature.
UR - http://www.scopus.com/inward/record.url?scp=85097311459&partnerID=8YFLogxK
U2 - 10.26508/LSA.202000907
DO - 10.26508/LSA.202000907
M3 - Article
AN - SCOPUS:85097311459
SN - 2575-1077
VL - 4
JO - Life Science Alliance
JF - Life Science Alliance
IS - 1
M1 - e202000907
ER -