Mesangial cells initiate compensatory tubular cell hypertrophy

I. Sinuani, I. Beberashvili, Z. Averbukh, M. Cohn, I. Gitelman, J. Weissgarten

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Unilateral nephrectomy results in compensatory renal growth, in which both the size and the functional capacity of the remaining kidney are increased. The functional adaptation to the removal of the contralateral kidney consists mostly of an increase in the glomerular filtration rate of the remaining kidney, and hypertrophy of cells comprising the nephron, mainly of the proximal tubular cells. Although the phenomenon of single kidney hypertrophy has been known for the past thousand years and despite intensive research over the past century, the mechanism of this process still remains unclear. The present article reviews the role of mesangial cells in compensatory renal hypertrophy.

Original languageEnglish
Pages (from-to)326-331
Number of pages6
JournalAmerican Journal of Nephrology
Volume31
Issue number4
DOIs
StatePublished - 1 Apr 2010

Keywords

  • Cell cycle
  • Compensatory growth
  • Growth factors
  • Hypertrophy
  • Mesangial cells
  • Tubular cell
  • Unilateral nephrectomy

ASJC Scopus subject areas

  • Nephrology

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