Mesenchymal stem cells and their derivatives as potential longevity-promoting tools

Ekaterina Rudnitsky; Alex Braiman; Marina Wolfson; Khachik K. Muradian; Vera Gorbunova; Gadi Turgeman; Vadim E. Fraifeld

doi:10.1007/s10522-025-10240-z

Mesenchymal stem cells and their derivatives as potential longevity-promoting tools

Ekaterina Rudnitsky, Alex Braiman, Marina Wolfson, Khachik K. Muradian, Vera Gorbunova, Gadi Turgeman, Vadim E. Fraifeld

Research output: Contribution to journal › Review article › peer-review

Abstract

Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.

Original language	English
Article number	96
Journal	Biogerontology
Volume	26
Issue number	3
DOIs	https://doi.org/10.1007/s10522-025-10240-z
State	Published - 1 Jun 2025

Keywords

Aging signatures
Cell therapy
Extracellular vesicles
Longevity
MSCs
Stem cells

ASJC Scopus subject areas

Aging
Gerontology
Geriatrics and Gerontology

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10.1007/s10522-025-10240-z

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title = "Mesenchymal stem cells and their derivatives as potential longevity-promoting tools",

abstract = "Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.",

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AU - Rudnitsky, Ekaterina

AU - Braiman, Alex

AU - Wolfson, Marina

AU - Muradian, Khachik K.

AU - Gorbunova, Vera

AU - Turgeman, Gadi

AU - Fraifeld, Vadim E.

N1 - Publisher Copyright: © The Author(s) 2025.

PY - 2025/6/1

Y1 - 2025/6/1

N2 - Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.

AB - Mesenchymal stem cells (MSCs) and blood plasma/MSC-derived extracellular vesicles (EVs) offer promising tools to promote longevity and treat age-related diseases. MSCs have low immunogenicity and tumorigenicity, and their efficacy is relatively independent of the donor age in humans (but not in rodents). Systemic administration of MSCs and stem cell/blood-derived EVs modified the omic profiles of various organs of aged rodents towards the young ones. The application of EVs appears to be even more beneficial than MSCs. Remarkably, over 70% of microRNAs, which are over-presented in ESC-derived EVs, were found to target longevity-associated genes. Along with MSCs, other types of stem cells were reported to display health- and lifespan-extending effects. Pluripotent Muse cells, a specific subpopulation of MSCs, which possess a number of unique features, could be particularly relevant for promoting healthspan. The rejuvenation potential of MSCs, EVs, and Muse cells warrants further investigation in both animal models and clinical trials, using aging clocks for biological age determination as one of the endpoints.

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KW - Cell therapy

KW - Extracellular vesicles

KW - Longevity

KW - MSCs

KW - Stem cells

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DO - 10.1007/s10522-025-10240-z

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Mesenchymal stem cells and their derivatives as potential longevity-promoting tools

Abstract

Keywords

ASJC Scopus subject areas

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