Metabolic remodelling of mice by hypoxic-hypercapnic environment: imitating the naked mole-rat

Denis A. Tolstun, Anna Knyazer, Tetiana V. Tushynska, Tatyana A. Dubiley, Vladislav V. Bezrukov, Vadim E. Fraifeld, Khachik K. Muradian

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not require external sources of gases or complex technical equipment. Here, we showed for the first time that a chronic exposure of mice to HHE could be a unique tool for NMR-like metabolic remodeling, resulting in a long-term and substantial decrease in metabolic rate, body temperature, and food consumption, without significant changes in expression of stress-related genes. Unexpectedly, the HHE accelerated skin wound healing, despite the lower energy expenditure. The self-produced HHE could be considered a model of voluntary calorie restriction. All in all, a chronic exposure to HHE offers a potential of being a lifespan-extending intervention as well as an efficient tool for treating the overweight and associated metabolic disorders.

Original languageEnglish
Pages (from-to)143-153
Number of pages11
Issue number2
StatePublished - 1 Apr 2020


  • Age
  • Hypercapnia
  • Hypometabolism
  • Hypothermia
  • Hypoxia
  • Mice
  • Voluntary calorie restriction

ASJC Scopus subject areas

  • Aging
  • Gerontology
  • Geriatrics and Gerontology


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