Metabolic Response to Point Mutations Reveals Principles of Modulation of in Vivo Enzyme Activity and Phenotype

Keyphrases

• Enzyme Activity 100%
• Point mutation 100%
• Metabolic Response 100%
• Methylenetetrahydrofolate Reductase (MTHFR) 100%
• Thymidylate Kinase 100%
• Filamentation 66%
• Reductase Activity 66%
• Molecular Mechanism 33%
• Escherichia Coli 33%
• High Concentration 33%
• System Level 33%
• Antibiotics 33%
• Sequence Variation 33%
• DNA Damage 33%
• In Vitro Activity 33%
• Genome Analysis 33%
• Cellular Environment 33%
• Hill Coefficient 33%
• Partial Loss 33%
• SOS Response 33%
• Trimethoprim 33%
• In Vivo Activity 33%
• Destabilizing mutations 33%
• Thymineless Death 33%
• Activity Curve 33%
• Bacterial Phenotype 33%
• Enzymatic Kinetics 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme Activity 100%
• Metabolic Pathway 100%
• Point Mutation 100%
• Dihydrofolate Reductase 100%
• Thymidylate Kinase 100%
• Thymidine Monophosphate 100%
• Thymidine Triphosphate 66%
• Enzyme 33%
• Protein Kinase A 33%
• DNA Damage 33%
• Escherichia coli 33%
• Trimethoprim 33%
• Enzyme Kinetics 33%
• Metabolomics 33%
• Hill Coefficient 33%