Metabolite amyloid-like fibrils interact with model membranes

Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Sofiya Kolusheva, Petr Král, Ehud Gazit

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

Original languageEnglish
Pages (from-to)4561-4564
Number of pages4
JournalChemical Communications
Volume54
Issue number36
DOIs
StatePublished - 1 Jan 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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