Metachronous pleomorphic adenomas occurring in the parotid and a minor salivary gland with genetic changes detected by comparative genomic hybridization

Bryony Southorn, Esther Manor, Lipa Bodner, Anne V. Spedding, Peter A. Brennan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A 32-year-old female underwent an extracapsular dissection for a pleomorphic adenoma (PA) of the parotid gland. Six months later, she presented with an increasing lump on the upper lip that, following excision, was confirmed to be a second PA. Formalin-fixed paraffin embedded tissues were analyzed for chromosomal aberrations. Comparative genomic hybridization analysis showed multiple chromosomal aberrations in the parotid PA. In comparison, no chromosomal aberrations were found in the lip PA. To our knowledge, metachronous benign pleomorphic adenomas occurring in both a major and minor salivary gland is unreported, and furthermore, there are no comparative genomic hybridization reports of this rare occurrence. We discuss the clinicopathological implications.

Original languageEnglish
Pages (from-to)805-808
Number of pages4
JournalJournal of Oral and Maxillofacial Surgery
Volume71
Issue number4
DOIs
StatePublished - 1 Apr 2013

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