Metagenomic Analysis Reveals Previously Undescribed Bat Coronavirus Strains in Eswatini

Julie Teresa Shapiro; Sarah Mollerup; Randi Holm Jensen; Jill Katharina Olofsson; Nam phuong D. Nguyen; Thomas Arn Hansen; Lasse Vinner; Ara Monadjem; Robert A. McCleery; Anders J. Hansen

doi:10.1007/s10393-021-01567-3

Metagenomic Analysis Reveals Previously Undescribed Bat Coronavirus Strains in Eswatini

Julie Teresa Shapiro, Sarah Mollerup, Randi Holm Jensen, Jill Katharina Olofsson, Nam phuong D. Nguyen, Thomas Arn Hansen, Lasse Vinner, Ara Monadjem, Robert A. McCleery, Anders J. Hansen

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We investigated the prevalence of coronaviruses in 44 bats from four families in northeastern Eswatini using high-throughput sequencing of fecal samples. We found evidence of coronaviruses in 18% of the bats. We recovered full or near-full-length genomes from two bat species: Chaerephon pumilus and Afronycteris nana, as well as additional coronavirus genome fragments from C. pumilus, Epomophorus wahlbergi, Mops condylurus, and Scotophilus dinganii. All bats from which we detected coronaviruses were captured leaving buildings or near human settlements, demonstrating the importance of continued surveillance of coronaviruses in bats to better understand the prevalence, diversity, and potential risks for spillover.

Original language	English
Pages (from-to)	421-428
Number of pages	8
Journal	EcoHealth
Volume	18
Issue number	4
DOIs	https://doi.org/10.1007/s10393-021-01567-3
State	Published - 1 Dec 2021

Keywords

Chiroptera
alphacoronavirus
betacoronavirus
emerging infectious diseases
human–wildlife interface
zoonotic disease

ASJC Scopus subject areas

Ecology
Health, Toxicology and Mutagenesis

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10.1007/s10393-021-01567-3

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title = "Metagenomic Analysis Reveals Previously Undescribed Bat Coronavirus Strains in Eswatini",

abstract = "We investigated the prevalence of coronaviruses in 44 bats from four families in northeastern Eswatini using high-throughput sequencing of fecal samples. We found evidence of coronaviruses in 18% of the bats. We recovered full or near-full-length genomes from two bat species: Chaerephon pumilus and Afronycteris nana, as well as additional coronavirus genome fragments from C. pumilus, Epomophorus wahlbergi, Mops condylurus, and Scotophilus dinganii. All bats from which we detected coronaviruses were captured leaving buildings or near human settlements, demonstrating the importance of continued surveillance of coronaviruses in bats to better understand the prevalence, diversity, and potential risks for spillover.",

keywords = "Chiroptera, alphacoronavirus, betacoronavirus, emerging infectious diseases, human–wildlife interface, zoonotic disease",

author = "Shapiro, {Julie Teresa} and Sarah Mollerup and Jensen, {Randi Holm} and Olofsson, {Jill Katharina} and Nguyen, {Nam phuong D.} and Hansen, {Thomas Arn} and Lasse Vinner and Ara Monadjem and McCleery, {Robert A.} and Hansen, {Anders J.}",

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year = "2021",

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doi = "10.1007/s10393-021-01567-3",

language = "English",

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AU - Shapiro, Julie Teresa

AU - Mollerup, Sarah

AU - Jensen, Randi Holm

AU - Olofsson, Jill Katharina

AU - Nguyen, Nam phuong D.

AU - Hansen, Thomas Arn

AU - Vinner, Lasse

AU - Monadjem, Ara

AU - McCleery, Robert A.

AU - Hansen, Anders J.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - We investigated the prevalence of coronaviruses in 44 bats from four families in northeastern Eswatini using high-throughput sequencing of fecal samples. We found evidence of coronaviruses in 18% of the bats. We recovered full or near-full-length genomes from two bat species: Chaerephon pumilus and Afronycteris nana, as well as additional coronavirus genome fragments from C. pumilus, Epomophorus wahlbergi, Mops condylurus, and Scotophilus dinganii. All bats from which we detected coronaviruses were captured leaving buildings or near human settlements, demonstrating the importance of continued surveillance of coronaviruses in bats to better understand the prevalence, diversity, and potential risks for spillover.

AB - We investigated the prevalence of coronaviruses in 44 bats from four families in northeastern Eswatini using high-throughput sequencing of fecal samples. We found evidence of coronaviruses in 18% of the bats. We recovered full or near-full-length genomes from two bat species: Chaerephon pumilus and Afronycteris nana, as well as additional coronavirus genome fragments from C. pumilus, Epomophorus wahlbergi, Mops condylurus, and Scotophilus dinganii. All bats from which we detected coronaviruses were captured leaving buildings or near human settlements, demonstrating the importance of continued surveillance of coronaviruses in bats to better understand the prevalence, diversity, and potential risks for spillover.

KW - Chiroptera

KW - alphacoronavirus

KW - betacoronavirus

KW - emerging infectious diseases

KW - human–wildlife interface

KW - zoonotic disease

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SN - 1612-9202

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EP - 428

JO - EcoHealth

JF - EcoHealth

IS - 4

ER -

Metagenomic Analysis Reveals Previously Undescribed Bat Coronavirus Strains in Eswatini

Abstract

Keywords

ASJC Scopus subject areas

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