Metal-enhanced bioluminescence: An approach for monitoring biological luminescent processes

Evgeni Eltzov, Daria Prilutsky, Ariel Kushmaro, Robert S. Marks, Chris D. Geddes

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


In this letter, the observation of metal (plasmon)-enhanced bioluminescence is reported. Bacteria, which are capable of generating specific bioluminescence signatures upon metabolic changes (general toxicity), have been studied from both glass and silvered glass microwell bottoms, where the silvered microwells have been modified with surface deposited silver island films (SiFs). The presence of the SiFs plasmon amplifies the near-field bioluminescence signatures, ≈<50 nm from the surface, enabling amplified detection of the reporter bioluminescence indicating sample toxicity. Using our approach a greater than fivefold enhancement in far-field bioluminescence occurs with much greater enhancements in the near-field predicted.

Original languageEnglish
Article number083901
JournalApplied Physics Letters
Issue number8
StatePublished - 6 Mar 2009

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)


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