Abstract
Iodine-catalysed efficient synthesis of 2-substituted benzimidazoles has been developed under aerobic condition. The one-pot oxidative cascade reactions of anilines, aldehydes and trimethylsilyl azide (TMSN3) lead to the benzimidazoles derivatives in the presence of tert-butyl hydroperoxide (TBHP). Iodine efficiently promoted the cross-coupling strategy to achieve the desired compounds via the sequential C[sbnd]H functionalization and cyclization. The present method features a greener approach, readily accessible reagents, broad substrate scope, high yields of the products, shorter reaction time and mild conditions.
Original language | English |
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Article number | 154289 |
Journal | Tetrahedron Letters |
Volume | 115 |
DOIs | |
State | Published - 31 Jan 2023 |
Externally published | Yes |
Keywords
- 2-Substituted benzimidazoles
- Gram-scale synthesis
- Iodine promoted
- Metal-free
- TMSN
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry