TY - JOUR
T1 - Metal-free oxidative coupling of aryl acetylene with elemental sulphur and amines
T2 - facile access to α-ketothioamides
AU - Sharma, Deepika
AU - Chatterjee, Rana
AU - Dhayalan, Vasudevan
AU - Dandela, Rambabu
N1 - Publisher Copyright:
© 2024 The Royal Society of Chemistry.
PY - 2024/7/2
Y1 - 2024/7/2
N2 - A simple and efficient oxidative coupling of aromatic alkynes with elemental sulphur and secondary amines has been reported. The iodine/DMSO system easily promoted the transformations, affording thioglyoxamides via C-S, C-O, and C-N bond formations. In this context, acetylenic C-H bond oxidation has occurred through iodination, leading to the desired products. Moreover, this metal-free, one-pot protocol is accomplished by using readily available starting materials, without external oxidants, and under aerobic conditions, providing a variety of α-ketothioamide compounds in moderate to good yields.
AB - A simple and efficient oxidative coupling of aromatic alkynes with elemental sulphur and secondary amines has been reported. The iodine/DMSO system easily promoted the transformations, affording thioglyoxamides via C-S, C-O, and C-N bond formations. In this context, acetylenic C-H bond oxidation has occurred through iodination, leading to the desired products. Moreover, this metal-free, one-pot protocol is accomplished by using readily available starting materials, without external oxidants, and under aerobic conditions, providing a variety of α-ketothioamide compounds in moderate to good yields.
UR - https://www.scopus.com/pages/publications/85198915175
U2 - 10.1039/d4ob00830h
DO - 10.1039/d4ob00830h
M3 - Article
C2 - 38993016
AN - SCOPUS:85198915175
SN - 1477-0520
VL - 22
SP - 5913
EP - 5917
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 29
ER -