Metastatic Malignant Melanoma with Spontaneous and Complete Regression of the Primary Lesion: Case Report and Review of the Literature

background. Spontaneous regression of malignant melanoma is characterized by a partial or complete disappearance of the neoplasm. Partial regression of melanoma has been documented in large series, but complete regression is reported as occurring only sporadically. objective. To describe a case of metastatic malignant melanoma where the primary lesion underwent spontaneous and complete regression and to review the literature pertaining to regression of melanoma. methods. The patient was examined clinically. Wide excision of the skin with the lesion was preformed as well as left inguinal lymph node dissection. results. Histologic examination of the lesion revealed complete regression of malignant melanoma. Examination of the lymph node dissected from the adjacent inguinal area revealed matastatic melanoma. conclusions. Greater attention should be devoted to identification of regression in melanoma, clinically and histologically, evaluating the prognostic implications which regression might indicate. 1994 American Society for Dermatologic Surgery, Inc.