Metastatic small cell lung cancer - an aggressive disease: a case report and literature review

Walid Shalata, Ismaell Massalha, Keren Rouvinov, Elron Oscar, Margarita Toker, Ashraf A-J, Yulia Dudnik, Alexander Yakobson

    Research output: Contribution to journalArticlepeer-review


    In the present case study, we describe a 53-year-old male with an aggressive small cell lung cancer (SCLC) that was diagnosed in January 2019. Our patient was treated as first line of systemic chemotherapy consisting of cisplatin and etoposide followed by mediastinal prophylactic radiotherapy with good response later he received for his metastatic disease (M-SCLC) a rechallenge of systemic chemotherapy consisting of carboplatin, etoposide and dulvalumab with stable disease and after progression his disease he was treated with lurbinectedin and after four cycles he reached a complete radiologic response. To the best of our knowledge, this is the first case to be reported of M-SCLC patient treated with prior of two types of platinum combination with immunotherapy and reaching a complete radiologic response.

    Original languageEnglish
    Pages (from-to)1138-1141
    Number of pages4
    JournalAnti-Cancer Drugs
    Issue number10
    StatePublished - 1 Nov 2021


    • complete response
    • lung disease
    • lurbinectedin
    • metastatic disease
    • small cell lung cancer

    ASJC Scopus subject areas

    • General Medicine


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