Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome

Giuseppe Morgante, Claudia Tosti, Raoul Orvieto, Maria C. Musacchio, Paola Piomboni, Vincenzo De Leo

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics.

Original languageEnglish
Pages (from-to)2150-2152
Number of pages3
JournalFertility and Sterility
Volume95
Issue number6
DOIs
StatePublished - 1 May 2011
Externally publishedYes

Keywords

  • Metabolic syndrome
  • OTA
  • metformin
  • semen
  • testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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