Methane as the product of reaction of methyl-coenzyme-M with monovalent nickel complexes in aqueous solutions. A model for the in vivo activity of cofactor F430

Israel Zilbermann, Gilad Golub, Haim Cohen, Dan Meyerstein

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Abstract

Solutions containing the monovalent macrocyclic nickel complexes 1 and 2 were prepared by irradiating with ionizing radiation He saturated solutions containing the divalent complexes and 0.01 M HCO2Na. Deaerated solutions containing methyl-coenzyme- M (MeCoM) were then injected into the vials containing the monovalent complexes. Vague traces of methane were detected at pH 7.4 while at pH 9.4 the yield of methane is over 10%. Blank experiments point out that MeCoM scavenges methyl free radicals via a mechanism which does not produce methane as the major product. A mechanism for the formation of methane in these reactions is proposed.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalInorganica Chimica Acta
Volume227
Issue number1
DOIs
StatePublished - 1 Dec 1994

Keywords

  • Enzyme complexes
  • Macrocyclic ligand complexes
  • Nickel complexes

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