Methods and Compositions for Treatment of Graft Rejection and Promotion of Graft Survival

Eli C Lewis (Inventor), Charles A Dinarello (Inventor), Leland Shapiro (Inventor)

    Research output: Patent

    Abstract

    Embodiments herein illustrate methods of treating, reducing or preventing transplantation rejection and/or side effects associated with transplantation. Some embodiments relate to compositions and methods for inhibition of graft rejection and promotion of graft survival. Other embodiments relate to modulation of cellular activities, including graft rejection, promotion of graft survival, graft versus host rejection and conditions commonly associated with graft rejection. Yet other embodiments relate to the inhibitory compounds comprising naturally occurring and man-made inhibitors of serine protease, derivatives and fragments of the carboxy-terminus of alpha1-antitrypsin and inducers of other alpha1-antitrypsin activities and uses thereof.
    Original languageEnglish GB
    Patent numberUS20090220518A1
    StatePublished - 1 Feb 2012

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