Methods for Treating Central Nervous System Disorders Using VDAC Inhibitors

Varda Shoshan-Barmatz (Inventor), GRUZMAN Arie Lev (Inventor), Arie Lev Gruzman (Inventor)

Research output: Patent


The present invention relates to use of small organic compounds interacting with the Voltage-Dependent Anion Channel (VDAC) for the treatment of diseases associated with central nervous system (CNS) disorders, including psychotic disorders, mood disorders, neurodegenerative diseases. In particular the present invention relates to the use of substituted piperazine- and piperidine-derivatives and pharmaceutical compositions comprising same for the treatment of psychotic disorders including schizophrenia, mood disorders, and neurodegenerative diseases.

Original languageEnglish
Patent numberUS2018078548
IPCA61K 31/ 495 A I
Priority date11/09/17
StatePublished - 22 Mar 2018


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