The present invention relates to compositions and methods for treating prediabetes and diabetes and delaying progression of the disease. The present invention uses molecules that specifically bind to and inhibit Voltage Dependent Anion Channel (VDAC1) that is expressed on the beta cells of diabetic subjects. Particularly, the present invention discloses the use of substituted piperazine and piperidine derivatives as specific inhibitors of VDAC1 for preventing the progression of and treating prediabetes and diabetes.
|IPC||A61P 3/ 10 A I|
|State||Published - 28 Jun 2018|