Microalgae as a source for VLC-PUFA production

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

31 Scopus citations

Abstract

Microalgae present a huge and still insufficiently tapped resource of very long-chain omega-3 and omega-6 polyunsaturated fatty acids (VLC-PUFA) for human nutrition and medicinal applications. This chapter describes the diversity of unicellular eukaryotic microalgae in respect to VLC-PUFA biosynthesis. Then, we outline the major biosynthetic pathways mediating the formation of VLC-PUFA by sequential desaturation and elongation of C18-PUFA acyl groups. We address the aspects of spatial localization of those pathways and elaborate on the role for VLC-PUFA in microalgal cells. Recent progress in microalgal genetic transformation and molecular engineering has opened the way to increased production efficiencies for VLC-PUFA. The perspectives of photobiotechnology and metabolic engineering of microalgae for altered or enhanced VLC-PUFA production are also discussed.

Original languageEnglish
Title of host publicationLipids in Plant and Algae Development
PublisherCham : Springer International Publishing : Imprint: Springer
Pages471-510
Number of pages40
Volume86
ISBN (Electronic)978-3-319-25979-6
ISBN (Print)978-3-319-25977-2
DOIs
StatePublished - 2016

Publication series

NameSub-Cellular Biochemistry
PublisherPlenum Publishers
ISSN (Print)0306-0225

Keywords

  • Biotechnology
  • Diversity
  • Lipid metabolism
  • Microalgae
  • Omega-3 LC-PUFA
  • Omega-6 LC-PUFA

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