Microfluidic model of the blood brain barrier

Hamilton Geraldine; Kerns Jordan; Kerns Jordan; Wen Norman; Lucchesi Carol; David Hinojosa Christopher; Fraser Jacob; Vatine Gad; Sances Samuel; Svendsen Clive; Levner Daniel; Sareen Dhruv

Microfluidic model of the blood brain barrier

Hamilton Geraldine (Inventor)
, Kerns Jordan (Inventor)
, Kerns Jordan (Inventor)
, Wen Norman (Inventor)
, Lucchesi Carol (Inventor)
, David Hinojosa Christopher (Inventor)
, Fraser Jacob (Inventor)
, Vatine Gad (Inventor)
, Sances Samuel (Inventor)
, Svendsen Clive (Inventor)
, Levner Daniel (Inventor)
, Sareen Dhruv (Inventor)

Department of Physiology and Cell Biology

Research output: Patent

Abstract

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

Original language	English
Patent number	GB2561312
IPC	C12N 5/ 0797 A I
Priority date	19/10/16
State	Published - 10 Oct 2018

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title = "Microfluidic model of the blood brain barrier",

abstract = "The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.",

author = "Hamilton Geraldine and Kerns Jordan and Kerns Jordan and Wen Norman and Lucchesi Carol and Christopher, \{David Hinojosa\} and Fraser Jacob and Vatine Gad and Sances Samuel and Svendsen Clive and Levner Daniel and Sareen Dhruv",

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language = "English",

type = "Patent",

note = "GB2561312; C12N 5/ 0797 A I",

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T1 - Microfluidic model of the blood brain barrier

AU - Geraldine, Hamilton

AU - Jordan, Kerns

AU - Norman, Wen

AU - Carol, Lucchesi

AU - Christopher, David Hinojosa

AU - Jacob, Fraser

AU - Gad, Vatine

AU - Samuel, Sances

AU - Clive, Svendsen

AU - Daniel, Levner

AU - Dhruv, Sareen

PY - 2018/10/10

Y1 - 2018/10/10

N2 - The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

AB - The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.

M3 - Patent

M1 - GB2561312

ER -

Microfluidic model of the blood brain barrier

Abstract

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