Abstract
Microneedle-mediated photodynamic/immunotherapy has emerged as a promising approach in the field of biomedical research, combining the benefits of both photodynamic therapy (PDT) and immunotherapy. This innovative technique utilizes the unique properties of microneedles to deliver photosensitizing agents and immunotherapeutic agents directly into the skin, enabling targeted and controlled treatment of various diseases, including cancer and infectious diseases. Photodynamic therapy involves the activation of photosensitizing agents by specific wavelengths of light, resulting in the generation of reactive oxygen species that selectively destroy cancer cells or pathogens. Immunotherapy, on the other hand, harnesses the body's immune system to recognize and eliminate diseased cells. Microneedles serve as minimally invasive delivery devices, capable of precisely and painlessly penetrating the skin to reach the target tissues. By integrating the two modalities, microneedle-mediated photodynamic/immunotherapy offers a synergistic approach to enhance treatment outcomes and potentially overcome limitations associated with individual therapies. It holds great promise for the treatment of various diseases, paving the way for more effective and personalized therapeutic interventions.
| Original language | English |
|---|---|
| Title of host publication | Design and Applications of Microneedles in Drug Delivery and Therapeutics |
| Publisher | Elsevier |
| Pages | 379-405 |
| Number of pages | 27 |
| ISBN (Electronic) | 9780443138812 |
| ISBN (Print) | 9780443138805 |
| DOIs | |
| State | Published - 1 Jan 2024 |
| Externally published | Yes |
Keywords
- Biomedical research
- Cancer treatment
- Drug delivery
- Immunotherapy
- Microneedles
- Photodynamic therapy
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology
