microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1: A Major Player in ROS Generation and Cancer Progression

Kuntal Dey; Soumasree De

doi:10.1007/978-981-16-5422-0_72

microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1: A Major Player in ROS Generation and Cancer Progression

Kuntal Dey, Soumasree De

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Cancer cells show elevated level of mitochondrial reactive species (mROS) generation. Voltage-dependent anion channel 1(VDAC1), an outer mitochondrial membrane (OMM) protein plays significant role in mitochondrial energy production as well as in metabolism. VDAC1 has been shown to influence the metastatic potential of cancer cells via production of mROS. Therefore, the regulation of VDAC1 expression seems an attractive area of research in cancer biology. Recent researches show that microRNA plays important roles in cancer metastasis by regulating expression of different proteins. In this context regulation of VDAC1 by microRNAs could be an attractive strategy as a therapeutic approach in cancer biology. Therefore, herein, we discuss the tumor suppressor role of several microRNAs in controlling the cancer progression network by targeting VDAC1 expression.

Original language	English
Title of host publication	Handbook of Oxidative Stress in Cancer
Subtitle of host publication	Therapeutic Aspects: Volume 1
Publisher	Springer Singapore
Pages	1429-1435
Number of pages	7
Volume	1
ISBN (Electronic)	9789811654220
ISBN (Print)	9789811654213
DOIs	https://doi.org/10.1007/978-981-16-5422-0_72
State	Published - 1 Jan 2022
Externally published	Yes

Keywords

Cancer
microRNAs
ROS
VDAC 1

ASJC Scopus subject areas

General Medicine
General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-981-16-5422-0_72

Cite this

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title = "microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1: A Major Player in ROS Generation and Cancer Progression",

abstract = "Cancer cells show elevated level of mitochondrial reactive species (mROS) generation. Voltage-dependent anion channel 1(VDAC1), an outer mitochondrial membrane (OMM) protein plays significant role in mitochondrial energy production as well as in metabolism. VDAC1 has been shown to influence the metastatic potential of cancer cells via production of mROS. Therefore, the regulation of VDAC1 expression seems an attractive area of research in cancer biology. Recent researches show that microRNA plays important roles in cancer metastasis by regulating expression of different proteins. In this context regulation of VDAC1 by microRNAs could be an attractive strategy as a therapeutic approach in cancer biology. Therefore, herein, we discuss the tumor suppressor role of several microRNAs in controlling the cancer progression network by targeting VDAC1 expression.",

keywords = "Cancer, microRNAs, ROS, VDAC 1",

author = "Kuntal Dey and Soumasree De",

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T1 - microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1

T2 - A Major Player in ROS Generation and Cancer Progression

AU - Dey, Kuntal

AU - De, Soumasree

N1 - Publisher Copyright: © Springer Nature Singapore Pte Ltd. 2022.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Cancer cells show elevated level of mitochondrial reactive species (mROS) generation. Voltage-dependent anion channel 1(VDAC1), an outer mitochondrial membrane (OMM) protein plays significant role in mitochondrial energy production as well as in metabolism. VDAC1 has been shown to influence the metastatic potential of cancer cells via production of mROS. Therefore, the regulation of VDAC1 expression seems an attractive area of research in cancer biology. Recent researches show that microRNA plays important roles in cancer metastasis by regulating expression of different proteins. In this context regulation of VDAC1 by microRNAs could be an attractive strategy as a therapeutic approach in cancer biology. Therefore, herein, we discuss the tumor suppressor role of several microRNAs in controlling the cancer progression network by targeting VDAC1 expression.

AB - Cancer cells show elevated level of mitochondrial reactive species (mROS) generation. Voltage-dependent anion channel 1(VDAC1), an outer mitochondrial membrane (OMM) protein plays significant role in mitochondrial energy production as well as in metabolism. VDAC1 has been shown to influence the metastatic potential of cancer cells via production of mROS. Therefore, the regulation of VDAC1 expression seems an attractive area of research in cancer biology. Recent researches show that microRNA plays important roles in cancer metastasis by regulating expression of different proteins. In this context regulation of VDAC1 by microRNAs could be an attractive strategy as a therapeutic approach in cancer biology. Therefore, herein, we discuss the tumor suppressor role of several microRNAs in controlling the cancer progression network by targeting VDAC1 expression.

KW - Cancer

KW - microRNAs

KW - ROS

KW - VDAC 1

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ER -

microRNAs-Mediated Regulation of Voltage Gated Anion Channel 1: A Major Player in ROS Generation and Cancer Progression

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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