Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Kishore Thalluri; Ashim Paul; Srinivasa Rao Manne; Dharm Dev; Bhubaneswar Mandal

doi:10.1039/c4ra09091h

Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Kishore Thalluri, Ashim Paul, Srinivasa Rao Manne, Dharm Dev, Bhubaneswar Mandal

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The synthesis of peptide alcohols from peptides bearing C-terminal amide using β-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.

Original language	English
Pages (from-to)	47841-47847
Number of pages	7
Journal	RSC Advances
Volume	4
Issue number	88
DOIs	https://doi.org/10.1039/c4ra09091h
State	Published - 1 Jan 2014
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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abstract = "The synthesis of peptide alcohols from peptides bearing C-terminal amide using β-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.",

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AU - Dev, Dharm

AU - Mandal, Bhubaneswar

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AB - The synthesis of peptide alcohols from peptides bearing C-terminal amide using β-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.

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Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Abstract

ASJC Scopus subject areas

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