Microwave assisted chemoselective organocatalytic peptide alcohol synthesis from C-terminal amide

Kishore Thalluri, Ashim Paul, Srinivasa Rao Manne, Dharm Dev, Bhubaneswar Mandal

Research output: Contribution to journalArticlepeer-review

Abstract

The synthesis of peptide alcohols from peptides bearing C-terminal amide using β-aminoalcohols is achieved by a simple, efficient, racemization-free (<1.5%), and chemoselective transformation in the presence of cost-effective PTSA (para-toluenesulfonic acid) under microwave irradiation. Peptide alcohols can be synthesized by a standard solid phase peptide synthesis protocol obviating the need for specially designed resin.

Original languageEnglish
Pages (from-to)47841-47847
Number of pages7
JournalRSC Advances
Volume4
Issue number88
DOIs
StatePublished - 1 Jan 2014
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry (all)
  • Chemical Engineering (all)

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