Mild cognitive impairment is associated with mild parkinsonian signs in a door-to-door study

Simon D. Israeli-Korn, Magda Massarwa, Edna Schechtman, Rosa Strugatsky, Shiri Avni, Lindsay A. Farrer, Robert P. Friedland, Rivka Inzelberg

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Mild cognitive impairment (MCI) and healthy aging have been shown to be associated with mild parkinsonian signs (MPS). We performed a door-to-door observational and follow-up study amongst consenting residents of Wadi Ara Arab villages in northern Israel aged ≥ 65 years (n=687) to examine whether MPS represent a risk factor for MCI and/or conversion from MCI to Alzheimer's disease (AD). In Phase 1, 223 cognitively normal (CN) and 173 MCI subjects were assessed by interview for medical history, neurological examination, motor part of the Unified Parkinson Disease Rating Scale (mUPDRS) (divided into item-clusters: axial, limb bradykinesia, tremor and rigidity) and cognitive tests. MCI subjects (n=111) were re-evaluated in Phase 2 for conversion to AD at least one year after initial assessment. MCI subjects had a higher frequency of axial dysfunction (8.7% vs. 1.3%) and limb bradykinesia (10.4% vs. 1.3%) than CN subjects (p <0.001, both). Stepwise logistic regression analysis estimating the probability of MCI vs. CN revealed higher mUPDRS (OR =1.19, 95% CI, 1.05 to 1.35, p=0.006) and higher limb bradykinesia scores (OR=1.75, 95% CI, 1.2 to 2.56, p=0.003) and not age as explanatory variables. Presence of MPS did not predict conversion to AD after adjustment for age and time-interval. These results suggest that axial and bradykinetic parkinsonian signs represent risk factors for MCI but MPS may not predict conversion from MCI to AD.

Original languageEnglish
Pages (from-to)1005-1013
Number of pages9
JournalJournal of Alzheimer's Disease
Issue number3
StatePublished - 1 Jan 2010


  • Aging
  • Alzheimer's disease
  • mild cognitive impairment
  • mild parkinsonian signs
  • neuroepidemiology
  • risk factors

ASJC Scopus subject areas

  • Neuroscience (all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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