Mild COVID-19 Was Not Associated with Impaired IVF Outcomes or Early Pregnancy Loss in IVF Patients

Yossef Kabalkin, Yaakov Bentov, Moran Gil, Ofer Beharier, Sireen Jaber, Arbel Moav-Zafrir, Dua’ Khwies, Assaf Ben-Meir, Efrat Esh Broder, Asnat Walfisch, Hananel E.G. Holzer, Anat Hershko Klement

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Data collection regarding the effects of COVID-19 on reproduction is ongoing. This study examined the effect of COVID-19 on IVF cycle parameters and early pregnancy outcomes. It included two arms: the first compared non-exposed cycles to post-SARS-CoV-2 IVF cycles. Sperm parameters were also compared. The second, prospective arm compared pregnancy outcomes among IVF patients who contracted COVID-19 during early pregnancy to those who did not. None of the patients were vaccinated against SARS-CoV-2. The first arm included 60 treatment cycles of women with confirmed COVID-19, compared to 60 non-exposed cycles (either the same patient before exposure or matched non-exposed patients). The outcomes of the treatment cycles did not differ significantly between exposed and non-exposed groups, including number of oocytes, endometrial thickness, fertilization rate and number of top-quality embryos. In 11 cycles, the male partner had also recently recovered: sperm concentration was lower post-exposure: 6.27 million/mL vs. 16.5 pre-exposure (p = 0.008). In 189 patients with IVF-achieved pregnancies, pregnancy loss and hospital admissions did not differ between exposed and non-exposed groups. IVF treatment outcomes and the rate of early pregnancy loss appears to be unaffected by SARS-CoV-2 disease, despite a minor decline in sperm concentration among recent recoverees.

Original languageEnglish
Article number5265
JournalJournal of Clinical Medicine
Issue number18
StatePublished - 1 Sep 2022
Externally publishedYes


  • COVID-19
  • SARS-CoV-2
  • in vitro fertilization
  • infertility
  • pregnancy outcomes

ASJC Scopus subject areas

  • General Medicine


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