Mimicking Horseradish Peroxidase Functions Using Cu2+-Modified Carbon Nitride Nanoparticles or Cu2+-Modified Carbon Dots as Heterogeneous Catalysts

Margarita Vázquez-González, Wei Ching Liao, Rémi Cazelles, Shan Wang, Xu Yu, Vitaly Gutkin, Itamar Willner

Research output: Contribution to journalArticlepeer-review

274 Scopus citations

Abstract

Cu2+-functionalized carbon nitride nanoparticles (Cu2+-g-C3N4 NPs), 200 nm, and Cu2+-carbon dots (Cu2+-C-dots), 8 nm, act as horseradish peroxidase-mimicking catalysts. The nanoparticles catalyze the generation of chemiluminescence in the presence of luminol/H2O2 and catalyze the oxidation of dopamine by H2O2 to form aminochrome. The Cu2+-g-C3N4-driven generation of chemiluminescence is used to develop a H2O2 sensor and is implemented to develop a glucose detection platform and a sensor for probing glucose oxidase. Also, the Cu2+-C-dots are functionalized with the β-cyclodextrin (β-CD) receptor units. The concentration of dopamine, at the Cu2+-C-dots' surface, by means of the β-CD receptor sites, leads to a 4-fold enhancement in the oxidation of dopamine by H2O2 to yield aminochrome compared to that of the unmodified C-dots.

Original languageEnglish
Pages (from-to)3247-3253
Number of pages7
JournalACS Nano
Volume11
Issue number3
DOIs
StatePublished - 28 Mar 2017
Externally publishedYes

Keywords

  • chemiluminescence
  • cyclodextrin
  • dopamine
  • glucose
  • sensor

ASJC Scopus subject areas

  • General Materials Science
  • General Engineering
  • General Physics and Astronomy

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