TY - JOUR
T1 - Mineral and endocrine metabolism during fracture healing in dogs
AU - Meller, Y.
AU - Kestenbaum, R. S.
AU - Mozes, M.
AU - Mozes, G.
AU - Yagil, R.
AU - Shany, S.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - The blood levels of parathormone (PTH), calcitonin (CT), vitamin D metabolites, calcium, phosphate, magnesium and alkaline phosphatase (AKP) were determined in 13 young dogs with experimental fractures of long bones. The parameters were measured before the fracture and during healing until the appearance of an early callus. Serum Ca levels were significantly reduced immediately after the fracture (10.95 ± 0.30 mg/dl to 10/25 ± 0.25 mg/dl; p<0.05). Significant rises in serum levels of PTH (0.99 ± 0.10 ng/ml to 1.57 ± 0.22 ng/ml; p<0.01); CT (0.14 ± 0.01 ng/ml to 0.18 ± 0.01 ng/ml; p<0.05; 24,25-dihydroxyvitamin D (13 ± 2 ng/ml to 19 ± 3 ng/ml; p<0.01) and AKP (153 ± 24 U/l to 211 ± 26 U/l; p<0.01) were noted during fracture repair. A reduction in serum levels of 25-hydroxyvitamin D (22 ± 2 ng/ml to 15 ± 1 ng/ml; p<0.001) was noted at the same time. The parameters returned or tended to return to normal levels during callus development. The data demonstrate the changes in levels of Ca-regulating hormones in response to bone injury. This suggests that CT and 24,25-dihydroxyvitamin D (24,25-(OH)2-D) can be associated with the process of callus formation.
AB - The blood levels of parathormone (PTH), calcitonin (CT), vitamin D metabolites, calcium, phosphate, magnesium and alkaline phosphatase (AKP) were determined in 13 young dogs with experimental fractures of long bones. The parameters were measured before the fracture and during healing until the appearance of an early callus. Serum Ca levels were significantly reduced immediately after the fracture (10.95 ± 0.30 mg/dl to 10/25 ± 0.25 mg/dl; p<0.05). Significant rises in serum levels of PTH (0.99 ± 0.10 ng/ml to 1.57 ± 0.22 ng/ml; p<0.01); CT (0.14 ± 0.01 ng/ml to 0.18 ± 0.01 ng/ml; p<0.05; 24,25-dihydroxyvitamin D (13 ± 2 ng/ml to 19 ± 3 ng/ml; p<0.01) and AKP (153 ± 24 U/l to 211 ± 26 U/l; p<0.01) were noted during fracture repair. A reduction in serum levels of 25-hydroxyvitamin D (22 ± 2 ng/ml to 15 ± 1 ng/ml; p<0.001) was noted at the same time. The parameters returned or tended to return to normal levels during callus development. The data demonstrate the changes in levels of Ca-regulating hormones in response to bone injury. This suggests that CT and 24,25-dihydroxyvitamin D (24,25-(OH)2-D) can be associated with the process of callus formation.
UR - http://www.scopus.com/inward/record.url?scp=0021196196&partnerID=8YFLogxK
U2 - 10.1097/00003086-198407000-00044
DO - 10.1097/00003086-198407000-00044
M3 - Article
C2 - 6744732
AN - SCOPUS:0021196196
SN - 0009-921X
VL - 187
SP - 289
EP - 295
JO - Clinical Orthopaedics and Related Research
JF - Clinical Orthopaedics and Related Research
ER -