Mining Plants for Bacterial Quorum Sensing Modulators

Shimrit David; Aviad Mandabi; Shaked Uzi; Asaph Aharoni; Michael M. Meijler

doi:10.1021/acschembio.7b00859

Mining Plants for Bacterial Quorum Sensing Modulators

Shimrit David, Aviad Mandabi, Shaked Uzi, Asaph Aharoni, Michael M. Meijler

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The bacterial plant pathogen Agrobacterium tumefaciens uses quorum sensing (QS) in order to regulate the transfer of DNA into the host plant genome, and this results in the induction of crown gall tumors. The deleterious results of these infections are widespread and affect many species of fruit and crops. In order to further our understanding of this process and to provide potential solutions, we evaluated a library of 3800 natural products from plant sources and identified potent compounds that are able to strongly modulate plant-bacterial interactions.

Original language	English
Pages (from-to)	247-252
Number of pages	6
Journal	ACS Chemical Biology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1021/acschembio.7b00859
State	Published - 19 Jan 2018

ASJC Scopus subject areas

Biochemistry
Molecular Medicine

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10.1021/acschembio.7b00859

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abstract = "The bacterial plant pathogen Agrobacterium tumefaciens uses quorum sensing (QS) in order to regulate the transfer of DNA into the host plant genome, and this results in the induction of crown gall tumors. The deleterious results of these infections are widespread and affect many species of fruit and crops. In order to further our understanding of this process and to provide potential solutions, we evaluated a library of 3800 natural products from plant sources and identified potent compounds that are able to strongly modulate plant-bacterial interactions.",

author = "Shimrit David and Aviad Mandabi and Shaked Uzi and Asaph Aharoni and Meijler, {Michael M.}",

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AU - Meijler, Michael M.

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AB - The bacterial plant pathogen Agrobacterium tumefaciens uses quorum sensing (QS) in order to regulate the transfer of DNA into the host plant genome, and this results in the induction of crown gall tumors. The deleterious results of these infections are widespread and affect many species of fruit and crops. In order to further our understanding of this process and to provide potential solutions, we evaluated a library of 3800 natural products from plant sources and identified potent compounds that are able to strongly modulate plant-bacterial interactions.

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Mining Plants for Bacterial Quorum Sensing Modulators

Abstract

ASJC Scopus subject areas

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