Miro1: New wheels for transferring mitochondria

Guy Las, Orian S. Shirihai

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Mesenchymal stem cells (MSC) are capable of protecting cells harboring mitochondrial damage. This protection is associated with the transfer of mitochondria through tunneling nanotubes (TNT) from MSC to the injured cells. In this issue of The EMBO Journal, the group of Anurag Agrawal shows that mitochondrial transfer is dependent on the levels of Miro1, a mitochondrial Rho-GTPase that regulates intercellular mitochondrial movement. Miro1 is the first protein shown to accelerate mitochondrial transfer. Amplifying the mitochondrial transfer phenomenon may allow for the study of the mechanisms that regulate it and contribute to our understanding of its role in disease and aging. The mitochondrial Rho-GTPase Miro1 regulates intercellular mitochondrial transfer between mesenchymal stem cells and epithelial cells in different models of epithelial lung injury.

Original languageEnglish
Pages (from-to)939-941
Number of pages3
JournalEMBO Journal
Volume33
Issue number9
DOIs
StatePublished - 2 May 2014

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology

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