Mitigating viral invasion: mTORC2’s role in neuroprotection and immunity

Ipsita Volety; Chandrashekhar D. Patil; Deepak Shukla

doi:10.1016/B978-0-12-817558-3.00008-1

Mitigating viral invasion: mTORC2’s role in neuroprotection and immunity

Ipsita Volety, Chandrashekhar D. Patil, Deepak Shukla

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

The mechanistic target of rapamycin (mTOR) forms two complexes, mTORC1 and mTORC2, with distinct functions. mTORC1 is widely characterized as a cell cycle, metabolism, and autophagy regulator. While not as widely studied, the rapamycin-insensitive counterpart, mTORC2, has recently been demonstrated to have crucial roles in mediating host innate immune function and autophagic response. Herpes simplex virus type 1 (HSV-1) remains a ubiquitous pathogen, capable of reprogramming host immunity to serve itself. Here, we discuss mTORC2’s immune associations and roles in the viral invasion of the host. We also describe our establishment of mTORC2 as a crucial host defense factor necessary for neuronal protection against HSV-1 infection through the mTORC2-Akt-FoxO3a axis.

Original language	English
Title of host publication	Stress
Subtitle of host publication	Immunology and Inflammation: Handbook of Stress Series Volume 5
Publisher	Elsevier
Pages	173-182
Number of pages	10
Volume	5
ISBN (Electronic)	9780128175583
ISBN (Print)	9780128175590
DOIs	https://doi.org/10.1016/B978-0-12-817558-3.00008-1
State	Published - 1 Jan 2023
Externally published	Yes

Keywords

Akt
FoxO3a
HSV-1
Host immune response
Neurodegeneration
Neuroprotection
Viruses
mTORC1
mTORC2

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/B978-0-12-817558-3.00008-1

Cite this

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title = "Mitigating viral invasion: mTORC2{\textquoteright}s role in neuroprotection and immunity",

abstract = "The mechanistic target of rapamycin (mTOR) forms two complexes, mTORC1 and mTORC2, with distinct functions. mTORC1 is widely characterized as a cell cycle, metabolism, and autophagy regulator. While not as widely studied, the rapamycin-insensitive counterpart, mTORC2, has recently been demonstrated to have crucial roles in mediating host innate immune function and autophagic response. Herpes simplex virus type 1 (HSV-1) remains a ubiquitous pathogen, capable of reprogramming host immunity to serve itself. Here, we discuss mTORC2{\textquoteright}s immune associations and roles in the viral invasion of the host. We also describe our establishment of mTORC2 as a crucial host defense factor necessary for neuronal protection against HSV-1 infection through the mTORC2-Akt-FoxO3a axis.",

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AB - The mechanistic target of rapamycin (mTOR) forms two complexes, mTORC1 and mTORC2, with distinct functions. mTORC1 is widely characterized as a cell cycle, metabolism, and autophagy regulator. While not as widely studied, the rapamycin-insensitive counterpart, mTORC2, has recently been demonstrated to have crucial roles in mediating host innate immune function and autophagic response. Herpes simplex virus type 1 (HSV-1) remains a ubiquitous pathogen, capable of reprogramming host immunity to serve itself. Here, we discuss mTORC2’s immune associations and roles in the viral invasion of the host. We also describe our establishment of mTORC2 as a crucial host defense factor necessary for neuronal protection against HSV-1 infection through the mTORC2-Akt-FoxO3a axis.

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KW - FoxO3a

KW - HSV-1

KW - Host immune response

KW - Neurodegeneration

KW - Neuroprotection

KW - Viruses

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KW - mTORC2

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ER -

Mitigating viral invasion: mTORC2’s role in neuroprotection and immunity

Abstract

Keywords

ASJC Scopus subject areas

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