Mitochondria membrane transformations in colon and prostate cancer and their biological implications

Shani Ben Zichri, Sofiya Kolusheva, Alexander Shames, Elina Abaev Schneiderman, Juan L. Poggio, David E. Stein, Elena Doubijensky, Dan Levy, Zulfiya Orynbayeva, Raz Jelinek

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mitochondria have emerged as important determinants in cancer progression and malignancy. However, the role of mitochondrial membranes in cancer onset and progression has not been thoroughly investigated. This study compares the structural and functional properties of mitochondrial membranes in prostate and colon cancer cells in comparison to normal mitochondria, and possible therapeutic implications of these membrane changes. Specifically, isolation of cell mitochondria and preparation of inverted sub-mitochondrial particles (SMPs) illuminated significant cancer-induced modulations of membrane lipid compositions, fluidity, and activity of cytochrome c oxidase, one of the key mitochondrial enzymes. The experimental data further show that cancer-associated membrane transformations may account for mitochondria targeting by betulinic acid and resveratrol, known anti-cancer molecules. Overall, this study probes the relationship between cancer and mitochondrial membrane transformations, underlying a potential therapeutic significance for mitochondrial membrane targeting in cancer.

Original languageEnglish
Article number183471
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1863
Issue number1
DOIs
StatePublished - 1 Jan 2021

Keywords

  • Betulinic acid
  • Cardiolipin
  • Colon cancer
  • Mitochondrial membrane
  • Prostate cancer
  • Resveratrol
  • Submitochondrial particles (SMPs)

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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