Mitochondrial and Nuclear Genome Coevolution

A. Blumberg, G. Barshad, D. Mishmar

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


The mitochondrion is the only organelle in animal cells with its own genome (mtDNA). Nevertheless, most mitochondrial proteins are encoded by the nuclear genome and are then imported into the mitochondria. Because animal mtDNA has a higher order of mutation rate compared to the nuclear genome, tight mitochondrial-nuclear coevolution is required to maintain mitochondrial function. Here we discuss three levels of such coevolution: protein-protein interaction within the mitochondrial oxidative phosphorylation system; nuclear-encoded protein-mtDNA-encoded RNA interactions in the mitochondrial translation system; nuclear DNA-encoded protein-mtDNA binding sites interactions as part of the mitochondrial transcription and replication machineries.

Original languageEnglish
Title of host publicationEncyclopedia of Evolutionary Biology
PublisherElsevier Inc.
Number of pages8
ISBN (Electronic)9780128004265
ISBN (Print)9780128000496
StatePublished - 14 Apr 2016


  • Co-regulation
  • Coevolution
  • MtDNA
  • Nuclear DNA
  • Protein-protein interaction
  • Regulation

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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