Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure

Marc Liesa, Orian S. Shirihai

Research output: Contribution to journalReview articlepeer-review

957 Scopus citations

Abstract

Mitochondrial fusion, fission, and mitophagy form an essential axis of mitochondrial quality control. However, quality control might not be the only task carried out by mitochondrial dynamics. Recent studies link mitochondrial dynamics to the balance between energy demand and nutrient supply, suggesting changes in mitochondrial architecture as a mechanism for bioenergetic adaptation to metabolic demands. By favoring either connected or fragmented architectures, mitochondrial dynamics regulates bioenergetic efficiency and energy expenditure. Placement of bioenergetic adaptation and quality control as competing tasks of mitochondrial dynamics might provide a new mechanism, linking excess nutrient environment to progressive mitochondrial dysfunction, common to age-related diseases.

Original languageEnglish
Pages (from-to)491-506
Number of pages16
JournalCell Metabolism
Volume17
Issue number4
DOIs
StatePublished - 2 Apr 2013

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure'. Together they form a unique fingerprint.

Cite this