Mitochondrial dynamics: The intersection of form and function

Andrew Ferree, Orian Shirihai

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

59 Scopus citations

Abstract

Mitochondria within a cell exist as a population in a dynamic -morphological continuum. The balance of mitochondrial fusion and fission dictates a spectrum of shapes from interconnected networks to fragmented individual units. This plasticity bestows the adaptive flexibility needed to adjust to changing cellular stresses and metabolic demands. The mechanisms that regulate mitochondrial dynamics, their importance in normal cell biology, and the roles they play in disease conditions are only beginning to be understood. Dysfunction of mitochondrial dynamics has been identified as a possible disease mechanism in Parkinson's disease. This chapter will introduce the budding field of mitochondrial dynamics and explore unique characteristics of affected neurons in Parkinson's disease that increase susceptibility to disruptions in mitochondrial dynamics.

Original languageEnglish
Title of host publicationMitochondrial Oxidative Phosphorylation
Subtitle of host publicationNuclear-Encoded Genes, Enzyme Regulation, and Pathophysiology
EditorsBernhard Kadenbach
Pages13-40
Number of pages28
DOIs
StatePublished - 17 Jul 2012
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume748
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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