Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, Or Lando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, William M. Philbrick, Ian R. Sweet, Orian H. Shirihai, Richard G. Kibbey

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Jesinkey et al. report that mitochondrial GTP (mtGTP) is an integrative nutrient sentinel regulating β cell function. Signaling from mtGTP raises calcium independent of oxidative phosphorylation to promote insulin secretion. Without overworking the β cell, mtGTP cycling potentiates insulin secretion, nutrient sensing, and mitochondrial expansion alongside promoting health and increasing insulin reserves.

Original languageEnglish
Pages (from-to)759-772.e10
JournalCell Reports
Volume28
Issue number3
DOIs
StatePublished - 16 Jul 2019
Externally publishedYes

Keywords

  • MIMOSA
  • PEPCK-M
  • anaplerosis
  • insulin secretion
  • metabolic flux
  • mitochondrial GTP
  • oxidative phosphorylation
  • phosphoenolpyruvate
  • stable isotope
  • succinyl-CoA synthetase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (all)

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