Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Sean R. Jesinkey; Anila K. Madiraju; Tiago C. Alves; Or Lando H. Yarborough; Rebecca L. Cardone; Xiaojian Zhao; Yassmin Parsaei; Ali R. Nasiri; Gina Butrico; Xinran Liu; Anthony J. Molina; Austin M. Rountree; Adam S. Neal; Dane M. Wolf; John Sterpka; William M. Philbrick; Ian R. Sweet; Orian H. Shirihai; Richard G. Kibbey

doi:10.1016/j.celrep.2019.06.058

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, Or Lando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, William M. Philbrick, Ian R. Sweet, Orian H. Shirihai, Richard G. Kibbey

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Jesinkey et al. report that mitochondrial GTP (mtGTP) is an integrative nutrient sentinel regulating β cell function. Signaling from mtGTP raises calcium independent of oxidative phosphorylation to promote insulin secretion. Without overworking the β cell, mtGTP cycling potentiates insulin secretion, nutrient sensing, and mitochondrial expansion alongside promoting health and increasing insulin reserves.

Original language	English
Pages (from-to)	759-772.e10
Journal	Cell Reports
Volume	28
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2019.06.058
State	Published - 16 Jul 2019
Externally published	Yes

Keywords

MIMOSA
PEPCK-M
anaplerosis
insulin secretion
metabolic flux
mitochondrial GTP
oxidative phosphorylation
phosphoenolpyruvate
stable isotope
succinyl-CoA synthetase

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.celrep.2019.06.058

Cite this

Jesinkey, S. R., Madiraju, A. K., Alves, T. C., Yarborough, O. L. H., Cardone, R. L., Zhao, X., Parsaei, Y., Nasiri, A. R., Butrico, G., Liu, X., Molina, A. J., Rountree, A. M., Neal, A. S., Wolf, D. M., Sterpka, J., Philbrick, W. M., Sweet, I. R., Shirihai, O. H., & Kibbey, R. G. (2019). Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Reports, 28(3), 759-772.e10. https://doi.org/10.1016/j.celrep.2019.06.058

@article{f13389061da74168a3383787f4de0761,

title = "Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos",

abstract = "Jesinkey et al. report that mitochondrial GTP (mtGTP) is an integrative nutrient sentinel regulating β cell function. Signaling from mtGTP raises calcium independent of oxidative phosphorylation to promote insulin secretion. Without overworking the β cell, mtGTP cycling potentiates insulin secretion, nutrient sensing, and mitochondrial expansion alongside promoting health and increasing insulin reserves.",

keywords = "MIMOSA, PEPCK-M, anaplerosis, insulin secretion, metabolic flux, mitochondrial GTP, oxidative phosphorylation, phosphoenolpyruvate, stable isotope, succinyl-CoA synthetase",

author = "Jesinkey, \{Sean R.\} and Madiraju, \{Anila K.\} and Alves, \{Tiago C.\} and Yarborough, \{Or Lando H.\} and Cardone, \{Rebecca L.\} and Xiaojian Zhao and Yassmin Parsaei and Nasiri, \{Ali R.\} and Gina Butrico and Xinran Liu and Molina, \{Anthony J.\} and Rountree, \{Austin M.\} and Neal, \{Adam S.\} and Wolf, \{Dane M.\} and John Sterpka and Philbrick, \{William M.\} and Sweet, \{Ian R.\} and Shirihai, \{Orian H.\} and Kibbey, \{Richard G.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Author(s)",

year = "2019",

month = jul,

day = "16",

doi = "10.1016/j.celrep.2019.06.058",

language = "English",

volume = "28",

pages = "759--772.e10",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

number = "3",

}

Jesinkey, SR, Madiraju, AK, Alves, TC, Yarborough, OLH, Cardone, RL, Zhao, X, Parsaei, Y, Nasiri, AR, Butrico, G, Liu, X, Molina, AJ, Rountree, AM, Neal, AS, Wolf, DM, Sterpka, J, Philbrick, WM, Sweet, IR, Shirihai, OH & Kibbey, RG 2019, 'Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos', Cell Reports, vol. 28, no. 3, pp. 759-772.e10. https://doi.org/10.1016/j.celrep.2019.06.058

TY - JOUR

T1 - Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

AU - Jesinkey, Sean R.

AU - Madiraju, Anila K.

AU - Alves, Tiago C.

AU - Yarborough, Or Lando H.

AU - Cardone, Rebecca L.

AU - Zhao, Xiaojian

AU - Parsaei, Yassmin

AU - Nasiri, Ali R.

AU - Butrico, Gina

AU - Liu, Xinran

AU - Molina, Anthony J.

AU - Rountree, Austin M.

AU - Neal, Adam S.

AU - Wolf, Dane M.

AU - Sterpka, John

AU - Philbrick, William M.

AU - Sweet, Ian R.

AU - Shirihai, Orian H.

AU - Kibbey, Richard G.

PY - 2019/7/16

Y1 - 2019/7/16

N2 - Jesinkey et al. report that mitochondrial GTP (mtGTP) is an integrative nutrient sentinel regulating β cell function. Signaling from mtGTP raises calcium independent of oxidative phosphorylation to promote insulin secretion. Without overworking the β cell, mtGTP cycling potentiates insulin secretion, nutrient sensing, and mitochondrial expansion alongside promoting health and increasing insulin reserves.

AB - Jesinkey et al. report that mitochondrial GTP (mtGTP) is an integrative nutrient sentinel regulating β cell function. Signaling from mtGTP raises calcium independent of oxidative phosphorylation to promote insulin secretion. Without overworking the β cell, mtGTP cycling potentiates insulin secretion, nutrient sensing, and mitochondrial expansion alongside promoting health and increasing insulin reserves.

KW - MIMOSA

KW - PEPCK-M

KW - anaplerosis

KW - insulin secretion

KW - metabolic flux

KW - mitochondrial GTP

KW - oxidative phosphorylation

KW - phosphoenolpyruvate

KW - stable isotope

KW - succinyl-CoA synthetase

UR - https://www.scopus.com/pages/publications/85068444780

U2 - 10.1016/j.celrep.2019.06.058

DO - 10.1016/j.celrep.2019.06.058

M3 - Article

C2 - 31315053

AN - SCOPUS:85068444780

SN - 2211-1247

VL - 28

SP - 759-772.e10

JO - Cell Reports

JF - Cell Reports

IS - 3

ER -

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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