TY - JOUR
T1 - MMP-2, TIMP-1, E-cadherin, and β;-catenin expression in endometrial serous carcinoma compared with low-grade endometrial endometrioid carcinoma and proliferative endometrium
AU - Shaco-Levy, Ruthy
AU - Sharabi, Shalom
AU - Piura, Benjamin
AU - Sion-Vardy, Netta
PY - 2008/8/22
Y1 - 2008/8/22
N2 - Objective. To investigate the expression of MMP-2, TIMP-1, E-cadherin and β-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium. Methods. We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low-grade EEC, and 10 cases of proliferative endometrium. Results. Compared with low-grade EEC, ESC showed significantly increased MMP-2 and TIMP-1 expression, as well as decreased membranous β-catenin staining. E-cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium. Conclusions. We suggest that MMP-2 and TIMP-1 expression and loss of β-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and β-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.
AB - Objective. To investigate the expression of MMP-2, TIMP-1, E-cadherin and β-catenin in endometrial serous carcinoma (ESC), low-grade endometrial endometrioid carcinoma (EEC), and proliferative endometrium. Methods. We performed an immunohistochemical study on 14 cases of ESC, 15 cases of low-grade EEC, and 10 cases of proliferative endometrium. Results. Compared with low-grade EEC, ESC showed significantly increased MMP-2 and TIMP-1 expression, as well as decreased membranous β-catenin staining. E-cadherin expression was significantly lower in ESC and EEC as compared with proliferative endometrium. Conclusions. We suggest that MMP-2 and TIMP-1 expression and loss of β-catenin have a role in the pathogenesis and progression of ESC. Decreased E-cadherin may have an important role in the development of both ESC and EEC. Furthermore, the dissimilarities in MMP-2, TIMP-1, E-cadherin and β-catenin expressions in ESC compared with EEC may be responsible, along with other factors, for their different biological behavior.
KW - β-catenin
KW - E-cadherin
KW - Endometrial endometrioid carcinoma
KW - Endometrial serous carcinoma
KW - Matrix metalloproteinases
UR - http://www.scopus.com/inward/record.url?scp=49649096620&partnerID=8YFLogxK
U2 - 10.1080/00016340802253775
DO - 10.1080/00016340802253775
M3 - Article
C2 - 18607832
AN - SCOPUS:49649096620
SN - 0001-6349
VL - 87
SP - 868
EP - 874
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
IS - 8
ER -
