Mode of inheritance of hand osteoarthritis in ethnically homogeneous pedigrees

Gregory Livshits, Leonid Kalichman, Zvi Cohen, Eugene Kobyliansky

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

The aim of the present study was to investigate the extent and mode of inheritance of hand osteoarthritis (OA) using a large sample of ethnically homogeneous pedigrees. Two types of segregation analysis (SA) models were examined. Type I models used the data adjusted for potential significant covariates, particularly age and sex, prior to genetic analysis. Type II models incorporated effects of the potential covariates into major gene penetrance functions, permitting an account of the genotype covariate-specific effect on study variables. The results of this study strongly supported the hypothesis of a major gene effect and additional multifactorial component. The best-fitting model was the Mendelian one with an additive type of inheritance. The estimates obtained using the standard three-factor variance decomposition analysis suggest that age (72.8%) and major gene (14.5%) are the main sources of interindividual differences in the development of hand OA. The contribution of the putative major gene on age- and sex-adjusted OA phenotype variation was 55% in the present study.

Original languageEnglish
Pages (from-to)849-860
Number of pages12
JournalHuman Biology
Volume74
Issue number6
DOIs
StatePublished - 1 Jan 2002
Externally publishedYes

Keywords

  • Genetics
  • Osteoarthritis
  • Segregation analysis

ASJC Scopus subject areas

  • General Medicine

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