Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Tatyana Kushner, Custon T. Nyabanga, Scott J. Cotler, Ohad Etzion, Harel Dahari

Research output: Contribution to journalArticlepeer-review

Abstract

Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

Original languageEnglish
Article numberofad027
JournalOpen Forum Infectious Diseases
Volume10
Issue number2
DOIs
StatePublished - 1 Feb 2023
Externally publishedYes

Keywords

  • antiviral therapy
  • hepatitis C virus
  • pregnancy
  • response-guided treatment

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology

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