Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Tatyana Kushner; Custon T. Nyabanga; Scott J. Cotler; Ohad Etzion; Harel Dahari

doi:10.1093/ofid/ofad027

Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Tatyana Kushner
, Custon T. Nyabanga
, Scott J. Cotler
, Ohad Etzion
, Harel Dahari

Research output: Contribution to journal › Article › peer-review

Abstract

Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

Original language	English
Article number	ofad027
Journal	Open Forum Infectious Diseases
Volume	10
Issue number	2
DOIs	https://doi.org/10.1093/ofid/ofad027
State	Published - 1 Feb 2023

Keywords

antiviral therapy
hepatitis C virus
pregnancy
response-guided treatment

ASJC Scopus subject areas

Oncology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/ofid/ofad027

Cite this

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title = "Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum",

abstract = "Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.",

keywords = "antiviral therapy, hepatitis C virus, pregnancy, response-guided treatment",

author = "Tatyana Kushner and Nyabanga, \{Custon T.\} and Cotler, \{Scott J.\} and Ohad Etzion and Harel Dahari",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.",

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doi = "10.1093/ofid/ofad027",

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TY - JOUR

T1 - Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

AU - Kushner, Tatyana

AU - Nyabanga, Custon T.

AU - Cotler, Scott J.

AU - Etzion, Ohad

AU - Dahari, Harel

PY - 2023/2/1

Y1 - 2023/2/1

N2 - Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

AB - Treating hepatitis C virus (HCV) in pregnancy would address HCV during prenatal care and potentially reduce the risk of vertical transmission. Response-guided therapy could provide a means to individualize and the reduce duration of HCV treatment during pregnancy. Data from a 27-year-old woman indicated that, pretreatment, HCV was stable and that it dropped in a biphasic manner during sofosbuvir/velpatasvir therapy, reaching target not detected at time of delivery-16days post-initiation of therapy. Mathematical modeling of measured HCV at days 0, 7, and 14 predicted that cure could have been achieved after 7weeks of sofosbuvir/velpatasvir, reducing the duration of therapy by 5weeks.

KW - antiviral therapy

KW - hepatitis C virus

KW - pregnancy

KW - response-guided treatment

UR - https://www.scopus.com/pages/publications/85159292012

U2 - 10.1093/ofid/ofad027

DO - 10.1093/ofid/ofad027

M3 - Article

C2 - 36776773

AN - SCOPUS:85159292012

SN - 2328-8957

VL - 10

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JF - Open Forum Infectious Diseases

IS - 2

M1 - ofad027

ER -

Modeling-Based Response-Guided Hepatitis C Treatment during Pregnancy and Postpartum

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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