Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients

Adequate Mhlanga; Rami Zakh; Alexander Churkin; Vladimir Reinharz; Jeffrey S. Glenn; Ohad Etzion; Scott J. Cotler; Cihan Yurdaydin; Danny Barash; Harel Dahari

doi:10.3390/math10203917

Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients

Adequate Mhlanga, Rami Zakh, Alexander Churkin, Vladimir Reinharz, Jeffrey S. Glenn, Ohad Etzion, Scott J. Cotler, Cihan Yurdaydin, Danny Barash, Harel Dahari

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

Original language	English
Article number	3917
Journal	Mathematics
Volume	10
Issue number	20
DOIs	https://doi.org/10.3390/math10203917
State	Published - 1 Oct 2022

Keywords

analytical solution
anti-HDV treatment
hepatitis B virus
hepatitis delta virus

ASJC Scopus subject areas

Computer Science (miscellaneous)
General Mathematics
Engineering (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/math10203917

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title = "Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients",

abstract = "Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.",

keywords = "analytical solution, anti-HDV treatment, hepatitis B virus, hepatitis delta virus",

author = "Adequate Mhlanga and Rami Zakh and Alexander Churkin and Vladimir Reinharz and Glenn, {Jeffrey S.} and Ohad Etzion and Cotler, {Scott J.} and Cihan Yurdaydin and Danny Barash and Harel Dahari",

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doi = "10.3390/math10203917",

language = "English",

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T1 - Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients

AU - Mhlanga, Adequate

AU - Zakh, Rami

AU - Churkin, Alexander

AU - Reinharz, Vladimir

AU - Glenn, Jeffrey S.

AU - Etzion, Ohad

AU - Cotler, Scott J.

AU - Yurdaydin, Cihan

AU - Barash, Danny

AU - Dahari, Harel

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

AB - Hepatitis D virus is an infectious subviral agent that can only propagate in people infected with hepatitis B virus. In this study, we modified and further developed a recent model for early hepatitis D virus and hepatitis B virus kinetics to better reproduce hepatitis D virus and hepatitis B virus kinetics measured in infected patients during anti-hepatitis D virus treatment. The analytical solutions were provided to highlight the new features of the modified model. The improved model offered significantly better prospects for modeling hepatitis D virus and hepatitis B virus interactions.

KW - analytical solution

KW - anti-HDV treatment

KW - hepatitis B virus

KW - hepatitis delta virus

UR - http://www.scopus.com/inward/record.url?scp=85140597185&partnerID=8YFLogxK

U2 - 10.3390/math10203917

DO - 10.3390/math10203917

M3 - Article

AN - SCOPUS:85140597185

SN - 2227-7390

VL - 10

JO - Mathematics

JF - Mathematics

IS - 20

M1 - 3917

ER -

Modeling the Interplay between HDV and HBV in Chronic HDV/HBV Patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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