Models of acetylation and the regulation of longevity: From yeast to humans

Moran Finkel, Haim Cohen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


In recent years it has emerged that acetylation, and especially the activity of certain deacetylases, regulates lifespan in model organisms. Among the three classes of deacetylases, the role of class III, sirtuins NAD+-dependent deacetylases, in regulating aging is the best studied. Sirtuins are conserved from bacteria to human and overexpression of sirtuins in yeast, nematodes and flies extends their lifespan, implying a conserved fundamental mechanism by which sirtuins regulate aging. In this review we will focus on the role of deacetylases, especially sirtuins, in regulating longevity and will describe and discuss their role in regulating lifespan from yeast to human.

Original languageEnglish
Pages (from-to)265-271
Number of pages7
JournalDrug Discovery Today: Disease Models
Issue number4
StatePublished - 1 Dec 2005
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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