Modified citrus pectin treatment in non-metastatic biochemically relapsed prostate cancer: Results of a prospective phase ii study

Daniel Keizman, Moshe Frenkel, Avivit Peer, Igal Kushnir, Eli Rosenbaum, David Sarid, Ilan Leibovitch, Roy Mano, Ofer Yossepowitch, David Margel, Ido Wolf, Ravit Geva, Hadas Dresler, Keren Rouvinov, Noa Rapoport, Isaac Eliaz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Optimal therapy of biochemically relapsed prostate cancer (BRPC) after local treatment is elusive. An established modified citrus pectin (PectaSol®, P-MCP), a dietary polysaccharide, is an established antagonist of galectin-3, a carbohydrate-binding protein involved in cancer pathogenesis. Based on PSA dynamics, we report on the safety and the primary outcome analysis of a prospective phase II study of P-MCP in non-metastatic BRPC based. Sixty patients were enrolled, and one patient withdrew after a month. Patients (n = 59) were given P-MCP, 4.8 grams X 3/day, for six months. The primary endpoint was the rate without PSA progression and improved PSA doubling time (PSADT). Secondary endpoints were the rate without radiologic progression and toxicity. Patients that did not progress by PSA and radiologically at six months continued for an additional twelve months. After six months, 78% (n = 46) responded to therapy, with a decreased/stable PSA in 58% (n = 34), or improvement of PSADT in 75% (n = 44), and with negative scans, and entered the second twelve months treatment phase. Median PSADT improved significantly (p = 0.003). Disease progression during the first 6 months was noted in only 22% (n = 13), with PSA progression in 17% (n = 10), and PSA and radiologic progression in 5% (n = 3). No patients developed grade 3 or 4 toxicity.

Original languageEnglish
Article number4295
JournalNutrients
Volume13
Issue number12
DOIs
StatePublished - 1 Dec 2021
Externally publishedYes

Keywords

  • Modified citrus pectin
  • Non-metastatic biochemically relapsed prostate cancer
  • PSA doubling time
  • PectaSol

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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