Modular and Multilayer Modeling — Application to Biological Processes

Michael B. Cutlip, Mordechai Shacham

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


Construction of dynamic simulation programs for complex processes is accomplished by a modular and sequential approach. The complex simulation model is broken down into smaller modules. These modules are modeled and tested using a mathematical software package that requires modest technical coding efforts for computer implementation of the model. The verified model is then used as the basis for the program that represents the entire process and for documentation. The proposed approach is demonstrated for the construction of a simulation program for semi-continuous fed-batch and cyclic-fed batch operation of a bioreactor. A simple and straightforward extension of the program enables optimization of the process with respect to various input variables. The effort required for the construction of the simulation program and the associated documentation is significantly reduced.

Original languageEnglish
Title of host publication17th European Symposium on Computer Aided Process Engineering
EditorsValentin Plesu, Paul Serban Agachi
Number of pages6
StatePublished - 1 Dec 2007

Publication series

NameComputer Aided Chemical Engineering
ISSN (Print)1570-7946


  • bioreactor
  • cyclic operation
  • dynamic simulation
  • fed-batch
  • modeling
  • optimization

ASJC Scopus subject areas

  • General Chemical Engineering
  • Computer Science Applications


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