@inbook{29a54d609dfd4d2283f850152f308703,
title = "Modular and Multilayer Modeling — Application to Biological Processes",
abstract = "Construction of dynamic simulation programs for complex processes is accomplished by a modular and sequential approach. The complex simulation model is broken down into smaller modules. These modules are modeled and tested using a mathematical software package that requires modest technical coding efforts for computer implementation of the model. The verified model is then used as the basis for the program that represents the entire process and for documentation. The proposed approach is demonstrated for the construction of a simulation program for semi-continuous fed-batch and cyclic-fed batch operation of a bioreactor. A simple and straightforward extension of the program enables optimization of the process with respect to various input variables. The effort required for the construction of the simulation program and the associated documentation is significantly reduced.",
keywords = "bioreactor, cyclic operation, dynamic simulation, fed-batch, modeling, optimization",
author = "\{B. Cutlip\}, Michael and Mordechai Shacham",
year = "2007",
month = dec,
day = "1",
doi = "10.1016/S1570-7946(07)80194-5",
language = "English",
isbn = "9780444531575",
series = "Computer Aided Chemical Engineering",
pages = "1019--1024",
editor = "Valentin Plesu and Agachi, \{Paul Serban\}",
booktitle = "17th European Symposium on Computer Aided Process Engineering",
}