Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia

David Abookasis; Marlon S. Mathews; Christopher Lay; Ron D. Frostig; Bruce J. Tromberg

doi:10.1117/12.713470

Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia

David Abookasis
, Marlon S. Mathews
, Christopher Lay
, Ron D. Frostig
, Bruce J. Tromberg

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

The authors report the results of utilizing spatially-modulated near infrared light using Modulated Imaging (MI) technology in imaging cerebral ischemia. MI images of the left parietal somatosensory cortex were obtained post-occlusion and up to three hours following middle cerebral artery occlusion. Tissue chromophore maps were obtained to demonstrate spatiotemporal changes in the distribution of oxy, deoxy, total hemoglobin, and oxygen saturation. MI recorded a decrease in oxyhemoglobin concentration and tissue oxygen saturation and increase in tissue deoxyhemoglobin concentration following occlusion. Optical intrinsic signal was used to detect functional activation of the somatosensory barrel cortex to whisker stimulation. This activation was completely lost following occlusion. Imaging findings in a transient ischemic attack using photothrombosis is also demonstrated.

Original language	English
Title of host publication	Medical Imaging 2007
Subtitle of host publication	Physiology, Function, and Structure from Medical Images
Edition	PART 1
DOIs	https://doi.org/10.1117/12.713470
State	Published - 15 Oct 2007
Externally published	Yes
Event	Medical Imaging 2007: Physiology, Function, and Structure from Medical Images - San Diego, CA, United States Duration: 18 Feb 2007 → 20 Feb 2007

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Number	PART 1
Volume	6511
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2007: Physiology, Function, and Structure from Medical Images
Country/Territory	United States
City	San Diego, CA
Period	18/02/07 → 20/02/07

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Brain attack
Ischemia
MCA stroke
Modulated imaging
Stroke
TIA

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Biomaterials
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.713470

Cite this

Abookasis, D., Mathews, M. S., Lay, C., Frostig, R. D., & Tromberg, B. J. (2007). Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia. In Medical Imaging 2007: Physiology, Function, and Structure from Medical Images (PART 1 ed.). Article 65110A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6511, No. PART 1). https://doi.org/10.1117/12.713470

@inproceedings{28013fa8f33d4ecc937bfd503d8a001a,

title = "Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia",

abstract = "The authors report the results of utilizing spatially-modulated near infrared light using Modulated Imaging (MI) technology in imaging cerebral ischemia. MI images of the left parietal somatosensory cortex were obtained post-occlusion and up to three hours following middle cerebral artery occlusion. Tissue chromophore maps were obtained to demonstrate spatiotemporal changes in the distribution of oxy, deoxy, total hemoglobin, and oxygen saturation. MI recorded a decrease in oxyhemoglobin concentration and tissue oxygen saturation and increase in tissue deoxyhemoglobin concentration following occlusion. Optical intrinsic signal was used to detect functional activation of the somatosensory barrel cortex to whisker stimulation. This activation was completely lost following occlusion. Imaging findings in a transient ischemic attack using photothrombosis is also demonstrated.",

keywords = "Brain attack, Ischemia, MCA stroke, Modulated imaging, Stroke, TIA",

author = "David Abookasis and Mathews, \{Marlon S.\} and Christopher Lay and Frostig, \{Ron D.\} and Tromberg, \{Bruce J.\}",

year = "2007",

month = oct,

day = "15",

doi = "10.1117/12.713470",

language = "English",

isbn = "0819466298",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

number = "PART 1",

booktitle = "Medical Imaging 2007",

edition = "PART 1",

note = "Medical Imaging 2007: Physiology, Function, and Structure from Medical Images ; Conference date: 18-02-2007 Through 20-02-2007",

}

Abookasis, D, Mathews, MS, Lay, C, Frostig, RD & Tromberg, BJ 2007, Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia. in Medical Imaging 2007: Physiology, Function, and Structure from Medical Images. PART 1 edn, 65110A, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, no. PART 1, vol. 6511, Medical Imaging 2007: Physiology, Function, and Structure from Medical Images, San Diego, CA, United States, 18/02/07. https://doi.org/10.1117/12.713470

Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia. / Abookasis, David; Mathews, Marlon S.; Lay, Christopher et al.
Medical Imaging 2007: Physiology, Function, and Structure from Medical Images. PART 1. ed. 2007. 65110A (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6511, No. PART 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Modulated imaging

T2 - Medical Imaging 2007: Physiology, Function, and Structure from Medical Images

AU - Abookasis, David

AU - Mathews, Marlon S.

AU - Lay, Christopher

AU - Frostig, Ron D.

AU - Tromberg, Bruce J.

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N2 - The authors report the results of utilizing spatially-modulated near infrared light using Modulated Imaging (MI) technology in imaging cerebral ischemia. MI images of the left parietal somatosensory cortex were obtained post-occlusion and up to three hours following middle cerebral artery occlusion. Tissue chromophore maps were obtained to demonstrate spatiotemporal changes in the distribution of oxy, deoxy, total hemoglobin, and oxygen saturation. MI recorded a decrease in oxyhemoglobin concentration and tissue oxygen saturation and increase in tissue deoxyhemoglobin concentration following occlusion. Optical intrinsic signal was used to detect functional activation of the somatosensory barrel cortex to whisker stimulation. This activation was completely lost following occlusion. Imaging findings in a transient ischemic attack using photothrombosis is also demonstrated.

AB - The authors report the results of utilizing spatially-modulated near infrared light using Modulated Imaging (MI) technology in imaging cerebral ischemia. MI images of the left parietal somatosensory cortex were obtained post-occlusion and up to three hours following middle cerebral artery occlusion. Tissue chromophore maps were obtained to demonstrate spatiotemporal changes in the distribution of oxy, deoxy, total hemoglobin, and oxygen saturation. MI recorded a decrease in oxyhemoglobin concentration and tissue oxygen saturation and increase in tissue deoxyhemoglobin concentration following occlusion. Optical intrinsic signal was used to detect functional activation of the somatosensory barrel cortex to whisker stimulation. This activation was completely lost following occlusion. Imaging findings in a transient ischemic attack using photothrombosis is also demonstrated.

KW - Brain attack

KW - Ischemia

KW - MCA stroke

KW - Modulated imaging

KW - Stroke

KW - TIA

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M3 - Conference contribution

AN - SCOPUS:35148867612

SN - 0819466298

SN - 9780819466297

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

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Y2 - 18 February 2007 through 20 February 2007

ER -

Modulated imaging: A novel method for quantifying tissue chromophores in evolving cerebral ischemia

Abstract

Publication series

Conference

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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