MODULATED RELEASE FROM POLYMERIC DRUG DELIVERY SYSTEMS USING OSCILLATING MAGNETIC FIELDS: IN VITRO AND IN VIVO CHARACTERISTICS.

E. R. Edelman, L. Brown, J. Kost, J. Taylor, R. Langer

Research output: Contribution to journalConference articlepeer-review

12 Scopus citations

Abstract

In earlier reports it was demonstrated that when small magnetic spheres or cylinders were embedded within polymer matrices impregnated with bovine serum album (BSA), rates of BSA release could be increased by the application of an oscillating magnetic field to these samples. This paper now reports on the implementation of an electromagnetic field source and greater control over the system parameters, examination of the dynamics of release regulation (e. g. timecourse of modulated events, stability of baseline and elevated levels), and a study of the effect of varying the amplitude of the magnetic field on modulated release both in vitro and in vivo.

Original languageEnglish
Pages (from-to)445-449
Number of pages5
JournalTransactions - American Society for Artificial Internal Organs
Volume30
StatePublished - 1 Dec 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (all)

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