MODULATED RELEASE FROM POLYMERIC DRUG DELIVERY SYSTEMS USING OSCILLATING MAGNETIC FIELDS: IN VITRO AND IN VIVO CHARACTERISTICS.

E. R. Edelman; L. Brown; J. Kost; J. Taylor; R. Langer

MODULATED RELEASE FROM POLYMERIC DRUG DELIVERY SYSTEMS USING OSCILLATING MAGNETIC FIELDS: IN VITRO AND IN VIVO CHARACTERISTICS.

E. R. Edelman, L. Brown, J. Kost, J. Taylor, R. Langer

Research output: Contribution to journal › Conference article › peer-review

13 Scopus citations

Abstract

In earlier reports it was demonstrated that when small magnetic spheres or cylinders were embedded within polymer matrices impregnated with bovine serum album (BSA), rates of BSA release could be increased by the application of an oscillating magnetic field to these samples. This paper now reports on the implementation of an electromagnetic field source and greater control over the system parameters, examination of the dynamics of release regulation (e. g. timecourse of modulated events, stability of baseline and elevated levels), and a study of the effect of varying the amplitude of the magnetic field on modulated release both in vitro and in vivo.

Original language	English
Pages (from-to)	445-449
Number of pages	5
Journal	Transactions - American Society for Artificial Internal Organs
Volume	30
State	Published - 1 Dec 1984
Externally published	Yes

ASJC Scopus subject areas

Medicine (all)

Cite this

@article{bf98fe26de31481a9dd46506c79da69f,

title = "MODULATED RELEASE FROM POLYMERIC DRUG DELIVERY SYSTEMS USING OSCILLATING MAGNETIC FIELDS: IN VITRO AND IN VIVO CHARACTERISTICS.",

abstract = "In earlier reports it was demonstrated that when small magnetic spheres or cylinders were embedded within polymer matrices impregnated with bovine serum album (BSA), rates of BSA release could be increased by the application of an oscillating magnetic field to these samples. This paper now reports on the implementation of an electromagnetic field source and greater control over the system parameters, examination of the dynamics of release regulation (e. g. timecourse of modulated events, stability of baseline and elevated levels), and a study of the effect of varying the amplitude of the magnetic field on modulated release both in vitro and in vivo.",

author = "Edelman, {E. R.} and L. Brown and J. Kost and J. Taylor and R. Langer",

year = "1984",

month = dec,

day = "1",

language = "English",

volume = "30",

pages = "445--449",

journal = "Transactions - American Society for Artificial Internal Organs",

issn = "0066-0078",

publisher = "Lippincott Williams and Wilkins Ltd.",

}

TY - JOUR

T1 - MODULATED RELEASE FROM POLYMERIC DRUG DELIVERY SYSTEMS USING OSCILLATING MAGNETIC FIELDS

T2 - IN VITRO AND IN VIVO CHARACTERISTICS.

AU - Edelman, E. R.

AU - Brown, L.

AU - Kost, J.

AU - Taylor, J.

AU - Langer, R.

PY - 1984/12/1

Y1 - 1984/12/1

N2 - In earlier reports it was demonstrated that when small magnetic spheres or cylinders were embedded within polymer matrices impregnated with bovine serum album (BSA), rates of BSA release could be increased by the application of an oscillating magnetic field to these samples. This paper now reports on the implementation of an electromagnetic field source and greater control over the system parameters, examination of the dynamics of release regulation (e. g. timecourse of modulated events, stability of baseline and elevated levels), and a study of the effect of varying the amplitude of the magnetic field on modulated release both in vitro and in vivo.

AB - In earlier reports it was demonstrated that when small magnetic spheres or cylinders were embedded within polymer matrices impregnated with bovine serum album (BSA), rates of BSA release could be increased by the application of an oscillating magnetic field to these samples. This paper now reports on the implementation of an electromagnetic field source and greater control over the system parameters, examination of the dynamics of release regulation (e. g. timecourse of modulated events, stability of baseline and elevated levels), and a study of the effect of varying the amplitude of the magnetic field on modulated release both in vitro and in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0021645517&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:0021645517

SN - 0066-0078

VL - 30

SP - 445

EP - 449

JO - Transactions - American Society for Artificial Internal Organs

JF - Transactions - American Society for Artificial Internal Organs

ER -

MODULATED RELEASE FROM POLYMERIC DRUG DELIVERY SYSTEMS USING OSCILLATING MAGNETIC FIELDS: IN VITRO AND IN VIVO CHARACTERISTICS.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this